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Alterations in gut #microbiome have been associated with #metabolic diseases such as #obesity and type 2 #diabetes ( #T2D); however, the changes in bacteria species or genomic composition are not clear. Previous animal studies have indicated that bacteria that are able to invade the epithelium may cause #inflammation that drives metabolic disorders. According to a new study published in the journal Cellular and Molecular Gastroenterology and Hepatology, researchers at Georgia ...State University have identified a correlation between bacteria invading the intestinal epithelium of the colon and the development of T2D. In this study, researchers used samples from patients at the Veteran's Administration Hospital in Atlanta. These individuals were at least 21 years old with no other health issues other than diabetes. They all had a colonoscopy in which two mucosal biopsies from the left colon were analyzed. As a result, researchers observed an inverse correlation between #microbiota epithelial distance and markers of metabolic syndrome (i.e., #BMI, fasting #glucose levels, #HA1C). The #microbiota epithelial distance was reduced by almost 3-fold in patients with T2D, and this pattern remained statistically significant even when all the #obese patients were removed from the analysis.These results indicate that bacterial encroachment is a feature of T2D and correlates with disease activity. The research team also probed colonic tissue sections for levels of various populations of mucosal immune cells in healthy individuals and those with diabetes. They observed a significant increase in cells that stained positive for CD19, a specific marker of B lymphocytes in the colon. This suggests the activation of mucosal B cells may result from microbiota encroachment. These alterations are an underlying cause of low-grade inflammation that desensitizes metabolic signaling and impairs #insulin and #leptin receptor signaling that promotes obesity and #dysglycemia. This is an interesting study and it brings to mind the compound #berberine. Many integrative health care providers are aware of berberine’s effect on lowering #glucose and its significant #antimicrobial activity against bacteria, #fungi, #parasites, worms, and #viruses, while having relatively sparing effects on the commensal bacteria. #Berberine blocks the adhesion of bacteria to epithelial cells, which may be one of the mechanisms of berberine’s antidiabetic effect by modulating the gut microbiome. Article By Michael Jurgelewicz, DC #functionalmedicine #functionalnutrition #nutrition #health #probiotics #Bwell #plainview #microbiome #guthealth See more

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The CoQ10-Statin Secret The medical literature clearly shows that #statin medications like Lipitor,Crestor, Zocor shut down the production of one of the most important nutrients in the body. And I am referring to Co-Enzyme Q10 (CoQ10). What many people are unaware of is the fact that when #CoQ10 is depleted it causes the LDL #cholesterol to become oxidized. This in turn sets off a cascade of events making the LDL cholesterol drill holes in the arterial wall causing major #inf...Continue reading