Organic-ese

By now you've reached reactions in #organicchemistry In the first semester one intermediate dominates your ability to write #mechanisms and that is the #carbenium ion or #carbocation. If you know Markovnikov's rule, this shouldn't be an issue, right? Wrong. Every time you create a carbocation remember this! If it can rearrange by a shift of a bond on an adjacent atom ([1,2-hydride, ring expansion or contractions, and attaining a lower energy state, it will do it spontaneous...ly. The point is you need to recognize. Stop whenever your mechanism leads you to a carbocation! (That means you must draw it first...get used to drawing every intermediate and it's accompanying resonance structures. Then consider if rearrangement will happen or not.

It's that time of year in #ochem...#nomenclature, #acids/bases, #resonance. Perhaps the most important skill is to get good at resonance as it will help all your reaction mechanisms in the future. Try this one, draw the arrows, formal charges, lone pairs, and determine which one is best (contributes most to the hybrid). Please circle it and explain in 5-6 words why it's the best.

So you can work the problems mainly by memorization. (It's not a criticism, everyone has to go through this in #organicchemistry). Many people still never understand or feel unable to draw (push) arrows. Yet that is the only way you will retain any of this. When the answers are given, the #mechanism is something you must be able to provide a reasonable hypothesis for. The "Fourth Variable" you need to fill in and takes up an entire page but earns a little partial credit, ma...ybe. Try the following. If the reaction has a name, denote it. Do not skip steps, formal charges, intermediates, resonance structure intermediates or the workup. Good luck. Answers posted on the weekend or by DM.

Are you in #OrganicChemistry 2? Doing #aromatic chemistry? Of course, you are. Here's a mechanism of the Electrophilic Aromatic Substitution reaction (#nitration). Can you explain the #regiochemistry of this transformation?

Treatment of (S) 2-bromobutane with sodium hydroxide results in the production of a compound with (R) configuration. The reaction has most likely taken place through: A. an SN1 mechanism B. an SN2 mechanism C. both an Sn1 and Sn2 reaction D. cannot be determined...Continue reading

Respond to the following question typical of exams approaching the end of semester one (#orgo 1). Treatment of (S) 2-bromobutane with sodium hydroxide results in the production of a compound with (R) configuration. The reaction has most likely taken place through: A. an SN1 mechanism B. an SN2 mechanism... C. both an Sn1 and Sn2 reaction D. cannot be determined Select the appropriate response and explain your logic (in words and/or diagrams) in reaching your choice of answer. Happy Saturday!

Have any questions (conceptually based)....no homework or quiz-type problems which can be spotted a mile away... ...just ask! You will get a response in the order received. Orgo is a marathon with no map. Reach the fountain (reactions!) as fast as you can. ... #homework #orgo #summersession.

How's Electrophilic Addition (#AdE3) in summer semester OrganicChemistry? The breaking of an #alkene or alkyne pi-bond to a positively-charged species (#electrophile) is #ratedetermining as it creates a #carbocation intermediate. Remember #Markovnikov's rule works for oxymercuration/(demercuration or reduction) or acid-catalyzed hydration. Simply: "The rich get richer: the carbon with more hydrogens at the start gain more hydrogen".... The former involving mercury (Hg(OAc)2) does not involve a carbocation but the latter (acid-catalyzed hydration) reacts through a carbocation intermediate. (What phenomenon is avoided by using the cyclic mercurinium ion instead of an ordinary carbocation?) Hydroboration and Oxymercuration are two of the most common and recurring reactions in first (and therefore second ) semester Organic even though they both synthesize alcohols from alkenes. Obviously, Hydroboration-Oxidation is different but how? In other words, why is it necessary to learn these 2 unusually lengthy (both mechanistically and the number of reagents to remember)? (Bonus: This question can be answered succinctly with a single word that starts with an "R" and ends with a "y".)

It is good to understand that everything you smell through your nose is a collection of organic molecules (physical objects) that bind and unbind to the receptors in your nose Those, in turn, are connected directly to the emotional and memory centers of the brain. This is why odors like the smell of rain can transport you back to images and emotions you haven’t revisited in decades. ... Often two distinct odors can come about such as limes and oranges which have the the same atom to atom connectivity and architecture but differ in symmetry or handedness by their relation as mirror images of the other: (#enantiomers) They are chiral molecules since they have chiral centers and no 2-fold symmetry. Below is an unmistakable odor, geosmin. I) Is this molecule #chiral or not? Are there tetrahedral (singly bonded) carbons attached to 4 different things? II) How many such carbons, if any, are there? a) 0 b) 1 c) 2 d) 3 e) 4 III) What functional group in geosmin is responsible for the odor of rain? IV) Designate the absolute configuration of any chiral carbon as R or S.

A highly efficient and regioselective Co(III)-catalyzed reaction of anilines with alkynes for a direct synthesis of a broad range of privileged quinolines: https://www.organic-chemistry.org/abstracts/lit6/196.shtm

https://tutors.com/providers/E1m21sdnB/review Seeking a tutor for organic chemistry? We have teamed up with Tutors.com and call help you online or locally with proven results time after time. Inquire in the link above. #college #chemistry #orgo #premed

If you’re in #OrganicChemistry 1, you have been exposed to a reaction intermediate that will appear and reappear throughout the semester. That intermediate is known as a carbocation or carbenium ion. The skills required to answer these questions are essential to your success in the course. If you have difficulties with this, seek help immediately.

Your Organic Chemistry course is starting to morph into a pile of nonsense or seems like little more than hour exercise in drawing structures or having PowerPoint slides read to you with no elaboration or indication of relevance. Sound familiar? You are not alone. Good luck with your organic course. We welcome your questions. So ask away! ... [Homework/Exam/Quiz type problems will not be answered publicly]